Article
Genome-wide association study of genetic variations associated with treatment failure after intravesical bacillus Calmette-Guérin therapy for non-muscle invasive bladder cancer.
Cancer immunology, immunotherapy : CII - 1 Jul 2020
Shiota Masaki, Fujimoto Naohiro, Yamamoto Yoshiaki, Takeuchi Ario, Tatsugami Katsunori, Uchiumi Takeshi, Matsuyama Hideyasu, Eto Masatoshi
Abstract excerpt
Bacillus Calmette-Guérin (BCG) instillation is a key therapy to manage non-muscle invasive bladder cancer (NMIBC). However, intravesical BCG therapy fails in approximately half of the patients, leading to recurrence and progression. We aimed to reveal the genetic variations associated with treatment failure after intravesical BCG therapy for NMIBC. This study included 91 Japanese patients treated with BCG...
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