Melanomas with activating RAF1 fusions: clinical, histopathologic, and molecular profiles

doi:10.1038/s41379-020-0510-7

Article

Melanomas with activating RAF1 fusions: clinical, histopathologic, and molecular profiles

2 Mar 2020

Abstract excerpt

A subset of melanomas is characterized by fusions involving genes that encode kinases. Melanomas with RAF1 fusions have been rarely reported, mostly in clinical literature. To investigate this distinctive group of melanomas, we searched for melanomas with activating structural variants in RAF1, utilizing our case archive of clinical samples with comprehensive genomic profiling (CGP) by a hybrid capture-based DNA...

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