Article
Identification of fusions with potential clinical significance in melanoma.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Dec 2022
Moran Jakob M T, Le Long P, Nardi Valentina, Golas Josephine, Farahani Alexander A, Signorelli Sylvia, Onozato Maristela L, Foreman Ruth K, Duncan Lyn M, Lawrence Donald P, Lennerz Jochen K, Dias-Santagata Dora, Hoang Mai P
Abstract excerpt
Though uncommon in melanoma, gene fusions may have therapeutic implications. Next generation sequencing-based clinical assays, designed to detect relevant gene fusions, mutations, and copy number changes, were performed on 750 melanomas (375 primary and 375 metastases) at our institution from 2014-2021. These included 599 (80%) cutaneous, 38 (5%) acral, 11 (1.5%) anorectal, 23 (3%) sinonasal, 27 (3.6%) eye...
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