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A hepatocyte differentiation model reveals two subtypes of liver cancer with different oncofetal properties and therapeutic targets

2 Mar 2020

Abstract excerpt

Clinical observation of the association between cancer aggressiveness and embryonic development stage implies the importance of developmental signals in cancer initiation and therapeutic resistance. However, the dynamic gene expression during organogenesis and the master oncofetal drivers are still unclear, which impeded the efficient elimination of poor prognostic tumors, including human hepatocellular carcinoma...

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PMID: 32123069
DOI: 10.1073/pnas.1912146117

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