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Design and Evaluation of a Method for Testing Polymorphisms of Folate-Related Genes Using the Luminex Liquichip System.

Genetic testing and molecular biomarkers - 1 Mar 2020

Jiang Xiwen, Huang Taosheng, Lin Weiping, Li Xinyu

Abstract excerpt

Purpose: The methylene tetrahydrofolate reductase (MTHFR) C677T, MTHFR A1298C, and the methionine synthase reductase (MTRR) A66G polymorphisms are the three most common folate metabolism-related loci in the Chinese population. They are associated with numerous birth defects or congenital diseases. To facilitate screening and genetic counseling, we established a method for the simultaneous detection of these three...

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PMID: 32119787
DOI: 10.1089/gtmb.2019.0202

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