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Standardization and application of ARMS TaqMan real-time PCR for screening of folate metabolism genes in Han Chinese.

Electrophoresis - 1 Nov 2024

Deng Peipei, Liu Xuan, Li Yuanjing, Li Huanhuan, Zhao Bangrong, Wang Shusong, Ma Jing

Abstract excerpt

Folate has antioxidant properties, and low concentration in seminal plasma may be associated with increased DNA damage in sperm. Mutations of the methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) genes, including MTHFR C677T (rs1801133), MTHFR A1298C (rs1801131), and MTRR A66G (rs1801394), can lead to decreased activity of the encoded folate metabolic enzymes, thereby affecting...

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Source

Identifiers

PMID: 39287077
DOI: 10.1002/elps.202400017

Genes

MTHFR
MTRR

Variants

rs1801133
rs1801133
rs1801133

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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