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Article

A simple oligonucleotide biochip capable of rapidly detecting known mitochondrial DNA mutations in Chinese patients with Leber's hereditary optic neuropathy (LHON).

Disease markers - 1 Jan 2011

Du Wei-Dong, Chen Gang, Cao Hui-Min, Jin Qing-Hui, Liao Rong-Feng, He Xiang-Cheng, Chen Da-Ben, Huang Shu-Ren, Zhao Hui, Lv Yong-Mei, Tang Hua-Yang, Tang Xian-Fa, Wang Yong-Qing, Sun Song, Zhao Jian-Long, Zhang Xue-Jun

Abstract excerpt

Leber's hereditary optic neuropathy (LHON) is a maternally transmitted disease. Clinically, no efficient assay protocols have been available. In this study, we aimed to develop an oligonucleotide biochip specialized for detection of known base substitution mutations in mitochondrial DNA causing LHON and to investigate frequencies of LHON relevant variants in Anhui region of China. Thirty-two pairs of...

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Identifiers

PMID: 21694444
DOI: 10.3233/DMA-2011-0767
PMCID: PMC3825074

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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