Article
A simple oligonucleotide biochip capable of rapidly detecting known mitochondrial DNA mutations in Chinese patients with Leber's hereditary optic neuropathy (LHON).
Disease markers - 1 Jan 2011
Du Wei-Dong, Chen Gang, Cao Hui-Min, Jin Qing-Hui, Liao Rong-Feng, He Xiang-Cheng, Chen Da-Ben, Huang Shu-Ren, Zhao Hui, Lv Yong-Mei, Tang Hua-Yang, Tang Xian-Fa, Wang Yong-Qing, Sun Song, Zhao Jian-Long, Zhang Xue-Jun
Abstract excerpt
Leber's hereditary optic neuropathy (LHON) is a maternally transmitted disease. Clinically, no efficient assay protocols have been available. In this study, we aimed to develop an oligonucleotide biochip specialized for detection of known base substitution mutations in mitochondrial DNA causing L...
Topics
- Adult
- China
- DNA Mutational Analysis
- DNA, Mitochondrial
- Feasibility Studies
- Female
- Humans
- Male
- Oligonucleotide Array Sequence Analysis
- Optic Atrophy, Hereditary, Leber
- Point Mutation
- Polymerase Chain Reaction
- Polymorphism, Single Nucleotide