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Article

A molecular-beacon-based asymmetric PCR assay for detecting polymorphisms related to folate metabolism.

Journal of clinical laboratory analysis - 1 Aug 2020

Peng Qi, Liao Shengbin, He Yuejing, Liang Liyun, Su Xiaohua, Rao Chunbao, Li Wenrui, Li Siping, Lu Xiaomei

Abstract excerpt

BACKGROUND: Polymorphisms (rs1801133 or C677T; rs1801131 or A1298C) of the MTHFR gene and rs1801394 (A66G) of the MTRR gene are important genetic determinants of folate metabolism. A convenient, sensitive, and reliable method is required to detect polymorphisms for the precise supplementation of folate. METHODS: A rapid detection method based on molecular beacon probes that can detect rs1801133, rs1801131, and...

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Share to Ferredoxin-NADP Reductase
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Identifiers

PMID: 32410296
DOI: 10.1002/jcla.23337
PMCID: PMC7439423

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