Article
Mutational and transcriptomic landscapes of a rare human prostate basal cell carcinoma.
The Prostate - 1 May 2020
Su Xianbin, Long Qi, Bo Juanjie, Shi Yi, Zhao Li-Nan, Lin Yingxin, Luo Qing, Ghazanfar Shila, Zhang Chao, Liu Qiang, Wang Lan, He Kunyan, He Jian, Cui Xiaofang, Yang Jean Y H, Han Ze-Guang, Yang Guoliang, Sha Jian-Jun
Abstract excerpt
BACKGROUND: As a rare subtype of prostate carcinoma, basal cell carcinoma (BCC) has not been studied extensively and thus lacks systematic molecular characterization. METHODS: Here, we applied single-cell genomic amplification and RNA-Seq to a specimen of human prostate BCC (CK34βE12+ /P63+ /PAP- /PSA- ). The mutational landscape was obtained via whole exome sequencing of the amplification mixture of 49 single...
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