Contralateral Breast Cancer Risk Among Carriers of Germline Pathogenic Variants in ATM, BRCA1, BRCA2, CHEK2, and PALB2.

doi:10.1200/JCO.22.01239

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Article

Contralateral Breast Cancer Risk Among Carriers of Germline Pathogenic Variants in ATM, BRCA1, BRCA2, CHEK2, and PALB2.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 20 Mar 2023

Yadav Siddhartha, Boddicker Nicholas J, Na Jie, Polley Eric C, Hu Chunling, Hart Steven N, Gnanaolivu Rohan D, Larson Nicole, Holtegaard Susan, Huang Huaizhi, Dunn Carolyn A, Teras Lauren R, Patel Alpa V, Lacey James V, Neuhausen Susan L, Martinez Elena, Haiman Christopher, Chen Fei, Ruddy Kathryn J, Olson Janet E, John Esther M, Kurian Allison W, Sandler Dale P, O'Brien Katie M, Taylor Jack A, Weinberg Clarice R, Anton-Culver Hoda, Ziogas Argyrios, Zirpoli Gary, Goldgar David E, Palmer Julie R, Domchek Susan M, Weitzel Jeffrey N, Nathanson Katherine L, Kraft Peter, Couch Fergus J

Abstract excerpt

PURPOSE: To estimate the risk of contralateral breast cancer (CBC) among women with germline pathogenic variants (PVs) in ATM, BRCA1, BRCA2, CHEK2, and PALB2. METHODS: The study population included 15,104 prospectively followed women within the CARRIERS study treated with ipsilateral surgery for invasive breast cancer. The risk of CBC was estimated for PV carriers in each gene compared with women without PVs in a...

Topics

Female
Humans
Ataxia Telangiectasia Mutated Proteins
Black or African American
BRCA1 Protein
BRCA2 Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Breast Neoplasms

Checkpoint Kinase 2

Fanconi Anemia Complementation Group N Protein

Genes, BRCA2

Genetic Predisposition to Disease

Germ-Line Mutation

Heterozygote

White

Source

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Identifiers

PMID: 36623243
DOI: 10.1200/JCO.22.01239
PMCID: PMC10022863

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