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How to Inactivate Human Ubiquitin E3 Ligases by Mutation

4 Feb 2020

Abstract excerpt

E3 ubiquitin ligases are the ultimate enzymes involved in the transfer of ubiquitin to substrate proteins, a process that determines the fate of the modified protein. Numerous diseases are caused by defects in the ubiquitin-proteasome machinery, including when the activity of a given E3 ligase is hampered. Thus, inactivation of E3 ligases and the resulting effects at molecular or cellular level have been the...

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PMID: 32117970
DOI: 10.3389/fcell.2020.00039

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