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Article

Role of the DNA repair genes H2AX and HMGB1 in human fat distribution and lipid profiles.

BMJ open diabetes research & care - 1 Feb 2020

Rohde Kerstin, Rønningen Torunn, la Cour Poulsen Lars, Keller Maria, Blüher Matthias, Böttcher Yvonne

Abstract excerpt

INTRODUCTION: Regional fat distribution strongly relates to metabolic comorbidities. We identified the DNA repair genes H2AX and HMGB1 to be differentially expressed between human subcutaneous (SAT) and omental visceral adipose tissue (OVAT) depots. As increased DNA damage is linked to metabolic disease, we here sought to analyze whether depot-specific H2AX and HMGB1 expression is related to anthropometric and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32114485
DOI: 10.1136/bmjdrc-2019-000831
PMCID: PMC7050360

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