Article
Large-scale genomics unveil polygenic architecture of human cortical surface area.
Nature communications - 20 Jul 2015
Chen Chi-Hua, Peng Qian, Schork Andrew J, Lo Min-Tzu, Fan Chun-Chieh, Wang Yunpeng, Desikan Rahul S, Bettella Francesco, Hagler Donald J, Westlye Lars T, Kremen William S, Jernigan Terry L, Le Hellard Stephanie, Steen Vidar M, Espeseth Thomas, Huentelman Matt, Håberg Asta K, Agartz Ingrid, Djurovic Srdjan, Andreassen Ole A, Schork Nicholas, Dale Anders M
Abstract excerpt
Little is known about how genetic variation contributes to neuroanatomical variability, and whether particular genomic regions comprising genes or evolutionarily conserved elements are enriched for effects that influence brain morphology. Here, we examine brain imaging and single-nucleotide polymorphisms (SNPs) data from ∼2,700 individuals. We show that a substantial proportion of variation in cortical surface...
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