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Article

Association of G472A allele of membrane bound catechol-O-methyltransferase gene with chronic post-sternotomy pain.

General thoracic and cardiovascular surgery - 1 Sept 2019

Dharaniprasad Goduguchintha, Samantaray Aloka, Hanumantha Rao Mangu, Chandra Abha, Sarma Potukuchi Venkata Gurunadha Krishna

Abstract excerpt

Chronic persistent surgical pain (CPSP) is a complex disease with strong genetic component. The studies on revealed association of mutations in membrane bound catechol-O-methyltransferase gene with CPSP were reported indifferent ethnic populations across the globe. We identify that one out of four patients who underwent sternotomy procedure showed CPSP even after 3 months of surgery. The Mb.COMT gene sequence...

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PMID: 30073475
DOI: 10.1007/s11748-018-0981-3

Genes

COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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