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Iron Status and Cancer Risk in UK Biobank: A Two-Sample Mendelian Randomization Study.

Nutrients - 19 Feb 2020

Yuan Shuai, Carter Paul, Vithayathil Mathew, Kar Siddhartha, Giovannucci Edward, Mason Amy M, Burgess Stephen, Larsson Susanna C

Abstract excerpt

We conducted a two-sample Mendelian randomization study to explore the associations of iron status with overall cancer and 22 site-specific cancers. Single-nucleotide polymorphisms for iron status were obtained from a genome-wide association study of 48,972 European-descent individuals. Summary-level data for breast and other cancers were obtained from the Breast Cancer Association Consortium and UK Biobank....

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PMID: 32092884
DOI: 10.3390/nu12020526
PMCID: PMC7071358

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