Article
Liver Iron Overload Drives COVID-19 Mortality: a Two-Sample Mendelian Randomization Study.
Biological trace element research - 1 Jun 2024
Tian Huimin, Kong Xiangjie, Han Fulei, Xing Fangjie, Zhu Shuai, Xu Tao, Wang Weijing, Song Ning, Wu Yili
Abstract excerpt
Iron overload has been associated with an increased risk of COVID-19 severity and mortality in observational studies, but it remains unclear whether these associations represent causal effects. We performed a two-sample Mendelian randomization (MR) to determine associations between genetic liability to iron overload and the risk of COVID-19 severity and mortality. From genome-wide association studies of European...
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