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Impact of U2AF1 Pathogenic Variants on Prognosis of Myelodysplastic Neoplasms With RUNX1 Mutation.

Hematological oncology - 1 Jul 2026

Liu Linlin, Li Bing, Qin Tiejun, Xu Zefeng, Qu Shiqiang, Pan Lijuan, Gao Qingyan, Jiao Meng, Bao Zefei, Liu Ningning, Jia Yujiao, Li Chengwen, Xiao Zhijian

Abstract excerpt

RUNX1 is one of the most commonly mutated genes in myelodysplastic neoplasms (MDS) and essential for hematopoiesis. However, clinical phenotype features of RUNX1 mutated patients and the interaction between RUNX1 and other genes mutations remains incompletely explored. We enrolled 1473 consecutive adult patients with primary MDS to investigate the laboratory, genomic characteristics, and survival of RUNX1-mutated...

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Aged
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Core Binding Factor Alpha 2 Subunit
SRSF2 gene
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Myelodysplastic Syndromes

Splicing Factor U2AF

Source

Identifiers

PMID: 42313655
DOI: 10.1002/hon.70212

Genes

RUNX1
U2AF1
ASXL1
NRAS
SRSF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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Impact of U2AF1 Pathogenic Variants on Prognosis of Myelodysplastic Neoplasms With RUNX1 Mutation.PMID 42313655Read ↗

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