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Article

S-nitrosylation affects TRAP1 structure and ATPase activity and modulates cell response to apoptotic stimuli.

Biochemical pharmacology - 1 Jun 2020

Faienza Fiorella, Lambrughi Matteo, Rizza Salvatore, Pecorari Chiara, Giglio Paola, Salamanca Viloria Juan, Allega Maria Francesca, Chiappetta Giovanni, Vinh Joëlle, Pacello Francesca, Battistoni Andrea, Rasola Andrea, Papaleo Elena, Filomeni Giuseppe

Abstract excerpt

The mitochondrial chaperone TRAP1 has been involved in several mitochondrial functions, and modulation of its expression/activity has been suggested to play a role in the metabolic reprogramming distinctive of cancer cells. TRAP1 posttranslational modifications, i.e. phosphorylation, can modify its capability to bind to different client proteins and modulate its oncogenic activity. Recently, it has been also...

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Identifiers

PMID: 32088262
DOI: 10.1016/j.bcp.2020.113869

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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