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Article

The fungal CCAAT-binding complex and HapX display highly variable but evolutionary conserved synergetic promoter-specific DNA recognition.

Nucleic acids research - 17 Apr 2020

Furukawa Takanori, Scheven Mareike Thea, Misslinger Matthias, Zhao Can, Hoefgen Sandra, Gsaller Fabio, Lau Jeffrey, Jöchl Christoph, Donaldson Ian, Valiante Vito, Brakhage Axel A, Bromley Michael J, Haas Hubertus, Hortschansky Peter

Abstract excerpt

To sustain iron homeostasis, microorganisms have evolved fine-tuned mechanisms for uptake, storage and detoxification of the essential metal iron. In the human pathogen Aspergillus fumigatus, the fungal-specific bZIP-type transcription factor HapX coordinates adaption to both iron starvation and iron excess and is thereby crucial for virulence. Previous studies indicated that a HapX homodimer interacts with the...

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PMID: 32086516
DOI: 10.1093/nar/gkaa109
PMCID: PMC7144946

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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