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Cooperative [2Fe-2S] cluster-binding regulates the functional transitions of the <i>Aspergillus fumigatus</i> iron regulator HapX for adaptation to iron starvation, sufficiency and excess

2024-11-28

Abstract excerpt

<h4>ABSTRACT</h4> Accurate sensing of cellular iron levels is vital, as this metal is essential but toxic in excess. The iron-sensing transcription factor HapX is crucial for virulence of Aspergillus fumigatus, the predominant human mold pathogen. Its absence impairs growth under iron limitation and excess, but not under moderate iron availability, suggesting that HapX switches between three states to adapt to v...

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Literature Corpus work
d343cbee-a074-5bb5-9b5a-39ea1acfb2e5
DOI
10.1101/2024.11.27.625597
Open publication

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Cooperative [2Fe-2S] cluster-binding regulates the functional transitions of the <i>Aspergillus fumigatus</i> iron regulator HapX for adaptation to iron starvation, sufficiency and excessDOI 10.1101/2024.11.27.625597
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