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Article

MEN1 deficiency stabilizes PD-L1 and promotes tumor immune evasion of lung cancer.

Cancer science - 1 Aug 2024

Zhang Cuncun, Sun Ningning, Fei Qingze, Peng Linlin, Wei Chengyu, Liu Xiangyu, Miao Sainan, Chai Mengqi, Wang Fang, Wang Di, Hong Jingfang, Huang Shenghai, Zhang Shihao, Qiu Huan

Abstract excerpt

Multiple Endocrine Neoplasia 1 gene (MEN1), which is known to be a tumor suppressor gene in lung tissues, encodes a 610 amino acid protein menin. Previous research has proven that MEN1 deficiency promotes the malignant progression of lung cancer. However, the biological role of this gene in the immune microenvironment of lung cancer remains unclear. In this study, we found that programmed cell death-ligand 1...

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Identifiers

PMID: 38685894
DOI: 10.1111/cas.16196
PMCID: PMC11309931

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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