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Mitochondrial tRNA sequences as unusual replication origins: pathogenic implications for Homo sapiens.

Journal of theoretical biology - 7 Dec 2006

Seligmann Hervé, Krishnan Neeraja M, Rao Basuthkar J

Abstract excerpt

The heavy strand of vertebrate mitochondrial genomes accumulates deaminations proportionally to the time it spends single-stranded during replication. A previous study showed that the strength of genome-wide deamination gradients originating from tRNA gene's locations increases with their capacities to form secondary structures resembling mitochondrial origins of light strand replication (OL), suggesting an...

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PMID: 16905154
DOI: 10.1016/j.jtbi.2006.06.028

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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