Article
The N-glycosylation of Equine Tetherin Affects Antiviral Activity by Regulating Its Subcellular Localization.
Viruses - 16 Feb 2020
Bai Bowen, Wang Xue-Feng, Zhang Mengmeng, Na Lei, Zhang Xiangmin, Zhang Haili, Yang Zhibiao, Wang Xiaojun
Abstract excerpt
Tetherin is an interferon-inducible type II transmembrane glycoprotein which inhibits the release of viruses, including retroviruses, through a "physical tethering" model. However, the role that the glycosylation of tetherin plays in its antiviral activity remains controversial. In this study, we found that mutation of N-glycosylation sites resulted in an attenuation of the antiviral activity of equine tetherin...
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