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Article

Somatic loss of estrogen receptor beta and p53 synergize to induce breast tumorigenesis.

Breast cancer research : BCR - 3 Jul 2017

Bado Igor, Nikolos Fotis, Rajapaksa Gayani, Wu Wanfu, Castaneda Jessica, Krishnamurthy Savitri, Webb Paul, Gustafsson Jan-Åke, Thomas Christoforos

Abstract excerpt

BACKGROUND: Upregulation of estrogen receptor beta (ERβ) in breast cancer cells is associated with epithelial maintenance, decreased proliferation and invasion, and a reduction in the expression of the receptor has been observed in invasive breast tumors. However, proof of an association between loss of ERβ and breast carcinogenesis is still missing. METHODS: To study the role of ERβ in breast oncogenesis, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28673316
DOI: 10.1186/s13058-017-0872-z
PMCID: PMC5494907

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