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Integrative multilevel exploration of the mechanism by which Er-Zhi-Wan alleviates the Parkinson's disease (PD)-like phenotype in the MPTP-induced PD mouse model.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 Sept 2023

Pan Botao, Niu Bo, He Yanjun, Zhou Cankun, Xia Chenglai

Abstract excerpt

The neuroprotective effects of Er-Zhi-Wan (EZW), a well-known traditional Chinese formulation, in MPTP-induced Parkinson's disease (PD) models are poorly understood and require evaluation. A model of PD induced by MPTP was used to evaluate the neuroprotective effects of EZW in mice. The underlying pharmacological mechanisms of EZW for the prevention and treatment of PD were then explored using a combination of...

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PMID: 37348406
DOI: 10.1016/j.biopha.2023.115021

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