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Article

Role of Cellular Senescence in Parkinson’s Disease: Potential for Disease-Modification Through Senotherapy

7 Jun 2025

Abstract excerpt

Parkinson's disease (PD) is an aging-related neurodegenerative disease characterized by a progressive loss of dopamine (DA)-secreting neurons in the substantia nigra. Most of the currently available treatments attempt to alleviate the disease symptoms by increasing DA transmission in the brain and are associated with unpleasant side effects. Since there are no treatments that modify the course of PD or regenerate...

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PMID: 40564120
DOI: 10.3390/biomedicines13061400

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