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Article

TRIF-dependent innate immune activation is critical for survival to neonatal gram-negative sepsis.

Journal of immunology (Baltimore, Md. : 1950) - 1 Feb 2015

Cuenca Alex G, Joiner Dallas N, Gentile Lori F, Cuenca Angela L, Wynn James L, Kelly-Scumpia Kindra M, Scumpia Philip O, Behrns Kevin E, Efron Philip A, Nacionales Dina, Lui Chao, Wallet Shannon M, Reeves Westley H, Mathews Clayton E, Moldawer Lyle L

Abstract excerpt

Current evidence suggests that neonatal immunity is functionally distinct from adults. Although TLR signaling through the adaptor protein, MyD88, has been shown to be critical for survival to sepsis in adults, little is known about the role of MyD88 or TRIF in neonatal sepsis. We demonstrate that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25548220
DOI: 10.4049/jimmunol.1302676
PMCID: PMC4297742

Genes

TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25548220-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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