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Article

The role of control region mitochondrial DNA mutations in cardiovascular disease: stroke and myocardial infarction.

Scientific reports - 17 Feb 2020

Umbria Miriam, Ramos Amanda, Aluja Maria Pilar, Santos Cristina

Abstract excerpt

Recent studies associated certain type of cardiovascular disease (CVD) with specific mitochondrial DNA (mtDNA) defects, mainly driven by the central role of mitochondria in cellular metabolism. Considering the importance of the control region (CR) on the regulation of the mtDNA gene expression, the aim of the present study was to investigate the role of mtDNA CR mutations in two CVDs: stroke and myocardial...

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Identifiers

PMID: 32066781
DOI: 10.1038/s41598-020-59631-x
PMCID: PMC7026394

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