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The mitochondrial DNA variant 16189T>C is associated with coronary artery disease and myocardial infarction in Saudi Arabs.

Genetic testing and molecular biomarkers - 1 Feb 2010

Abu-Amero Khaled K, Al-Boudari Olyan M, Mousa Ahmed, Gonzalez Ana M, Larruga Jose M, Cabrera Vicente M, Dzimiri Nduna

Abstract excerpt

By virtue of the functional role of the mitochondrion in energy and reactive oxygen species production, mutations in mitochondrial DNA (mtDNA) are potential candidates for cardiovascular-related disorders. Further, the mtDNA is extremely polymorphic and several diagnostic single-nucleotide polymorphisms have been used to assort sequences into haplogroups with defined continental and regional ranges. However, the...

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Identifiers

PMID: 20143910
DOI: 10.1089/gtmb.2009.0095

Genes

CAD

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