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Article

High resolution melting analysis for a rapid identification of heterozygous and homozygous sequence changes in the MUTYH gene.

BMC cancer - 21 Jul 2011

Tricarico Rossella, Crucianelli Francesca, Alvau Antonio, Orlando Claudio, Sestini Roberta, Tonelli Francesco, Valanzano Rosa, Genuardi Maurizio

Abstract excerpt

BACKGROUND: MUTYH-associated polyposis (MAP) is an autosomal recessive form of intestinal polyposis predisposing to colorectal carcinoma. High resolution melting analysis (HRMA) is a mutation scanning method that allows detection of heterozygous sequence changes with high sensitivity, whereas homozygosity for a nucleotide change may not lead to significant curve shape or melting temperature changes compared to...

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Source

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Identifiers

PMID: 21777424
DOI: 10.1186/1471-2407-11-305
PMCID: PMC3156810

Genes

MUTYH

Provenance

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