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Article

N_LyST: a simple and rapid screening test for Lynch syndrome.

Journal of clinical pathology - 1 Aug 2018

Susanti Susanti, Fadhil Wakkas, Ebili Henry Okuchukwu, Asiri Abutaleb, Nestarenkaite Ausrine, Hadjimichael Efthymios, Ham-Karim Hersh A, Field Joanne, Stafford Katherine, Matharoo-Ball Balwir, Hassall James C, Sharif Abid, Oniscu Anca, Ilyas Mohammad

Abstract excerpt

AIMS: We sought to use PCR followed by high-resolution melting analysis to develop a single closed-tube screening panel to screen for Lynch syndrome. This comprises tests for microsatellite instability (MSI), MLH1 methylation promoter and BRAF mutation. METHODS: For MSI testing, five mononucleotide markers (BAT25, BAT26, BCAT25, MYB, EWSR1) were developed. In addition, primers were designed to interrogate Region...

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Share to Colorectal Neoplasms, Hereditary Nonpolyposis
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29472252
DOI: 10.1136/jclinpath-2018-205013

Genes

BRAF
MLH1
EWSR1
MSH2
MSH6
MYB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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