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Article

Mutation of outer-shell residues modulates metal ion co-ordination strength in a metalloenzyme.

The Biochemical journal - 15 Jul 2010

Foo Jee-Loon, Jackson Colin J, Carr Paul D, Kim Hye-Kyung, Schenk Gerhard, Gahan Lawrence R, Ollis David L

Abstract excerpt

The metal ion co-ordination sites of many metalloproteins have been characterized by a variety of spectroscopic techniques and small-molecule model systems, revealing many important insights into the structural determinants of metal ion co-ordination. However, our understanding of this fundamentally and practically important phenomenon remains frustratingly simplistic; in many proteins it is essentially...

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Catalytic Domain
Crystallography, X-Ray
Directed Molecular Evolution
Kinetics
Metalloproteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Conformation

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PMID: 20459397
DOI: 10.1042/BJ20100233

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