Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Extracellular Matrix Signalling and Injury Susceptibility: ACAN and FMOD Variants in Sports-Related Musculoskeletal Injuries.

Genes - 17 Apr 2026

Rzeszutko-Bełzowska Agata, Leońska-Duniec Agata

Abstract excerpt

Background/Objectives: Musculoskeletal soft-tissue injuries are common among physically active individuals and arise from complex interactions between environmental and biological factors. Genetic variation in genes involved in extracellular matrix (ECM) organization may contribute to individual susceptibility to such injuries. This study investigated whether polymorphisms in aggrecan (ACAN, rs2351491 and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aggrecans
Share to Extracellular Matrix

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Polymorphism, Single Nucleotide

Share to Signal Transduction

Share to Young Adult

Source

Open in PubMed Open full text

Identifiers

PMID: 42074594
DOI: 10.3390/genes17040475
PMCID: PMC13116978

Genes

ACAN
FMOD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Extracellular Matrix Signalling and Injury Susceptibility: ACAN and FMOD Variants in Sports-Related Musculoskeletal Injuries.PMID 42074594Read ↗

The Role of COL1A1, COL5A1, ACTN3, MMP3, and GDF5 Gene Variants in Common Sports Injuries: Systematic Review of ACL Rupture, Achilles Tendinopathy, and Stress Fractures.Semantic proximity Read ↗

Genes encoding proteoglycans are associated with the risk of anterior cruciate ligament ruptures.Semantic proximity Read ↗

Modulators of the extracellular matrix and risk of anterior cruciate ligament ruptures.Semantic proximity Read ↗

Biological variation in musculoskeletal injuries: current knowledge, future research and practical implications.Semantic proximity Read ↗

Genetic risk factors for musculoskeletal soft tissue injuries.Semantic proximity Read ↗

Genetic Polymorphisms Associated with Non-Contact Muscle Injuries and Exercise-Induced Muscle Damage: A Systematic ReviewSemantic proximity Read ↗

Genome-Wide Association Screens for Anterior Cruciate Ligament TearsSemantic proximity Read ↗

Two genetic loci associated with ankle injury.Semantic proximity Read ↗

The interaction of polymorphisms in extracellular matrix genes and underlying miRNA motifs that modulate susceptibility to anterior cruciate ligament rupture.Semantic proximity Read ↗

Genetic variants within the COL5A1 gene are associated with ligament injuries in physically active populations from Australia, South Africa, and Japan.Semantic proximity Read ↗

The Genetic Basis of Non-Contact Soft Tissue Injuries-Are There Practical Applications of Genetic Knowledge?Semantic proximity Read ↗

Genetic susceptibility to anterior cruciate ligament rupture in athletes: a genome-wide association case–control studySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.