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Article

Significance of minimal residual disease in pediatric mixed phenotype acute leukemia: a multicenter cohort study.

Leukemia - 1 Jul 2020

Oberley Matthew J, Raikar Sunil S, Wertheim Gerald B, Malvar Jemily, Sposto Richard, Rabin Karen R, Punia Jyotinder N, Seif Alix E, Cahen Viviane C, Schore Reuven J, Luca Dragos C, Guinipero Terri, Woods William G, O'Gorman Maurice R G, Orgel Etan

Abstract excerpt

The rarity of mixed phenotype acute leukemia (MPAL) has precluded adequate data to incorporate minimal residual disease (MRD) monitoring into therapy. Fluidity in MPAL classification systems further complicates understanding its biology and outcomes; this includes uncertainty surrounding the impact of shifting diagnostic requirements even between iterations of the World Health Organization (WHO) classification....

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Identifiers

PMID: 32060402
DOI: 10.1038/s41375-020-0741-0
PMCID: PMC7332384

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