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Article

Ongoing Notch signaling maintains phenotypic fidelity in the adult exocrine pancreas.

Developmental biology - 1 Feb 2012

Kopinke Daniel, Brailsford Marisa, Pan Fong Cheng, Magnuson Mark A, Wright Christopher V E, Murtaugh L Charles

Abstract excerpt

The Notch signaling pathway regulates embryonic development of the pancreas, inhibiting progenitor differentiation into exocrine acinar and endocrine islet cells. The adult pancreas appears to lack progenitor cells, and its mature cell types are maintained by the proliferation of pre-existing differentiated cells. Nonetheless, Notch remains active in adult duct and terminal duct/centroacinar cells (CACs), in...

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Identifiers

PMID: 22146645
DOI: 10.1016/j.ydbio.2011.11.010
PMCID: PMC3254730

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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