Article
A SNP of bacterial blc disturbs gut lysophospholipid homeostasis and induces inflammation through epithelial barrier disruption.
EBioMedicine - 1 Feb 2020
Zou Dayuan, Pei Jingwen, Lan Jianfeng, Sang Hong, Chen Hongjuan, Yuan Haoliang, Wu Di, Zhang Yuanyuan, Wang Yufang, Wang Dingyu, Zou Yujie, Chen Di, Ren Jianan, Gao Xiang, Lin Zhaoyu
Abstract excerpt
BACKGROUND: Alteration of commensal bacterial composition is associated with many inflammatory diseases. However, few studies have pinpointed the specific bacterial genes that may suppress host immune responses against microbes and maintain homeostasis in the host intestine. METHODS: High-throughput screening was performed in Caenorhabditis elegans with a single gene knockout ut screening was performed in...
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