Article
The Rhomboid Protease GlpG Promotes the Persistence of Extraintestinal Pathogenic Escherichia coli within the Gut.
Infection and immunity - 1 Jun 2017
Russell Colin W, Richards Amanda C, Chang Alexander S, Mulvey Matthew A
Abstract excerpt
Extraintestinal pathogenic Escherichia coli (ExPEC) strains are typically benign within the mammalian gut but can disperse to extraintestinal sites to cause diseases like urinary tract infections and sepsis. As occupation of the intestinal tract is often a prerequisite for ExPEC-mediated pathogenesis, we set out to understand how ExPEC colonizes this niche. A screen using transposon sequencing (Tn-seq) was...
Topics
- Animals
- DNA-Binding Proteins
- Endopeptidases
- Escherichia coli Infections
- Escherichia coli Proteins
- Extraintestinal Pathogenic Escherichia coli
- Female
- Gastrointestinal Tract
- Genetic Fitness
- Intestinal Mucosa