Article
Identification of an analgesic lipopeptide produced by the probiotic Escherichia coli strain Nissle 1917.
Nature communications - 3 Nov 2017
Pérez-Berezo Teresa, Pujo Julien, Martin Patricia, Le Faouder Pauline, Galano Jean-Marie, Guy Alexandre, Knauf Claude, Tabet Jean Claude, Tronnet Sophie, Barreau Frederick, Heuillet Maud, Dietrich Gilles, Bertrand-Michel Justine, Durand Thierry, Oswald Eric, Cenac Nicolas
Abstract excerpt
Administration of the probiotic Escherichia coli strain Nissle 1917 (EcN) decreases visceral pain associated with irritable bowel syndrome. Mutation of clbA, a gene involved in the biosynthesis of secondary metabolites, including colibactin, was previously shown to abrogate EcN probiotic activity. Here, we show that EcN, but not an isogenic clbA mutant, produces an analgesic lipopeptide. We characterize lipoamino...
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