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Article

Determinants of mesial temporal lobe volume loss in older individuals with preserved cognition: a longitudinal PET amyloid study.

Neurobiology of aging - 1 Mar 2020

Montandon Marie-Louise, Herrmann François R, Garibotto Valentina, Rodriguez Cristelle, Haller Sven, Giannakopoulos Panteleimon

Abstract excerpt

Mesial temporal lobe (MTL) is prominently affected in normal aging and associated with neurodegeneration in AD. Whether or not MTL atrophy is dependent on increasing amyloid load before the emergence of cognitive deficits is still disputed. We performed a 4.5-year longitudinal study in 75 older community dwellers (48 women, mean age: 79.3 years) including magnetic resonance imaging at baseline and follow-up,...

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Identifiers

PMID: 32057528
DOI: 10.1016/j.neurobiolaging.2019.12.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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