Article
Genetic Predisposition to Breast and Ovarian Cancers: How Many and Which Genes to Test?
International journal of molecular sciences - 8 Feb 2020
Angeli Davide, Salvi Samanta, Tedaldi Gianluca
Abstract excerpt
Breast and ovarian cancers are some of the most common tumors in females, and the genetic predisposition is emerging as one of the key risk factors in the development of these two malignancies. BRCA1 and BRCA2 are the best-known genes associated with hereditary breast and ovarian cancer. However, recent advances in molecular techniques, Next-Generation Sequencing in particular, have led to the identification of...
Topics
- Breast Neoplasms
- Female
- Genetic Predisposition to Disease
- High-Throughput Nucleotide Sequencing
- Humans
- Ovarian Neoplasms
- PTEN Phosphohydrolase
- Tumor Suppressor Protein p53