Article
Regenerative lineages and immune-mediated pruning in lung cancer metastasis.
Nature medicine - 1 Feb 2020
Laughney Ashley M, Hu Jing, Campbell Nathaniel R, Bakhoum Samuel F, Setty Manu, Lavallée Vincent-Philippe, Xie Yubin, Masilionis Ignas, Carr Ambrose J, Kottapalli Sanjay, Allaj Viola, Mattar Marissa, Rekhtman Natasha, Xavier Joao B, Mazutis Linas, Poirier John T, Rudin Charles M, Pe'er Dana, Massagué Joan
Abstract excerpt
Developmental processes underlying normal tissue regeneration have been implicated in cancer, but the degree of their enactment during tumor progression and under the selective pressures of immune surveillance, remain unknown. Here we show that human primary lung adenocarcinomas are characterized by the emergence of regenerative cell types, typically seen in response to lung injury, and by striking infidelity...
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