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Article

Epigenetic modifications: novel therapeutic strategies for systemic sclerosis?

1 Jul 2011

Abstract excerpt

Epigenetic modifications of gene expression comprise modifications of DNA by DNA methylation and modifications of the histone proteins by acetylation, methylation, SUMOylation or phosphorylation. DNA methylation in the promoter region of genes represses gene transcription. Histone modifications influence the structure of DNA and regulate gene expression by changing the availability of DNA for the transcriptional...

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PMID: 21790290
DOI: 10.1586/eci.11.37

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