Article
Scope and Predictive Genetic/Phenotypic Signatures of Bicarbonate (NaHCO3) Responsiveness and β-Lactam Sensitization in Methicillin-Resistant Staphylococcus aureus.
Antimicrobial agents and chemotherapy - 21 Apr 2020
Ersoy Selvi C, Otmishi Mariam, Milan Vanessa T, Li Liang, Pak Youngju, Mediavilla Jose, Chen Liang, Kreiswirth Barry, Chambers Henry F, Proctor Richard A, Xiong Yan Q, Fowler Vance G, Bayer Arnold S
Abstract excerpt
Addition of sodium bicarbonate (NaHCO3) to standard antimicrobial susceptibility testing medium reveals certain methicillin-resistant Staphylococcus aureus (MRSA) strains to be highly susceptible to β-lactams. We investigated the prevalence of this phenotype (NaHCO3 responsiveness) to two β-lactams among 58 clinical MRSA bloodstream isolates. Of note, ∼75% and ∼36% of isolates displayed the NaHCO3 responsiveness...
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