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Article

Environmental factors modulate β-lactamase phenotypes: effect of pH and redox potential on β-lactam resistance.

Microbiology spectrum - 4 Aug 2026

Anbo Mikkel, Jensen Jacob Dyring, Ivanova Mirena, Nielsen Hanne Nørgaard, Svendsen Christina Aaby, Otani Saria, Aarestrup Frank M

Abstract excerpt

Environmental factors may have unnoticed effects on the activity of β-lactamases against β-lactams. We constructed a panel of Escherichia coli strains expressing 16 different β-lactamases and determined the MICs of 10 β-lactams under aerobic conditions at different pH values and under anaerobic conditions. We observed a contrasting effect of pH on MICs depending on the β-lactam and β-lactamase. Anaerobiosis...

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Aerobiosis
Anaerobiosis
beta-Lactam Resistance
beta-Lactamases
beta-Lactams

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Hydrogen-Ion Concentration

Oxidation-Reduction

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Identifiers

PMID: 42466904
DOI: 10.1128/spectrum.01453-26
PMCID: PMC13436003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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