Article
Phenotypic and genotypic correlates of the sodium bicarbonate-responsive phenotype among methicillin-resistant Staphylococcus aureus isolates from skin and soft-tissue infections.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases - 1 Apr 2025
Ersoy Selvi C, Madrigal Sabrina L, Chen Liang, Mediavilla Jose, Kreiswirth Barry, Flores Evelyn A, Miller Loren G, Xiong Yan Q, Harrison Ewan M, Blane Beth, Peacock Sharon J, Patel Robin, Chambers Henry F, Bayer Arnold S, Proctor Richard A
Abstract excerpt
OBJECTIVES: The objective of this study is to assess the frequency of the novel sodium bicarbonate (NaHCO3)-responsive phenotype, wherein clinical methicillin-resistant Staphylococcus aureus (MRSA) isolates are rendered susceptible to standard-of-care β-lactams in the presence of NaHCO3, in a collection of 103 clinical U.S. MRSA skin and soft-tissue infection (SSTI) isolates and 22 clinical European SSTI...
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