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Bicarbonate Within: A Hidden Modulator of Antibiotic Susceptibility

16 Jan 2025

Abstract excerpt

Since its standardization, clinical antimicrobial susceptibility testing (AST) has relied upon a standard medium, Mueller-Hinton Broth/Agar (MHB/A), to determine antibiotic resistance. However, this microbiologic medium bears little resemblance to the host milieu, calling into question the physiological relevance of resistance phenotypes it reveals. Recent studies investigating antimicrobial susceptibility in...

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PMID: 39858381
DOI: 10.3390/antibiotics14010096

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