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Article

Role of the NaHCO3 Transporter MpsABC in the NaHCO3-β-Lactam-Responsive Phenotype in Methicillin-Resistant Staphylococcus aureus.

Microbiology spectrum - 15 Jun 2023

Fan Sook-Ha, Proctor Richard A, Ersoy Selvi C, Manna Adhar C, Cheung Ambrose L, Götz Friedrich, Chambers Henry F, Bayer Arnold S

Abstract excerpt

Methicillin-resistant Staphylococcus aureus (MRSA) infections are an increasing concern due to their intrinsic resistance to most standard-of-care β-lactam antibiotics. Recent studies of clinical isolates have documented a novel phenotype, termed NaHCO3 responsiveness, in which a substantial proportion of MRSA strains exhibit enhanced susceptibility to β-lactams such as cefazolin and oxacillin in the presence of...

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Identifiers

PMID: 37102972
DOI: 10.1128/spectrum.00141-23
PMCID: PMC10269494

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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