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Article

Skin barrier dysfunction measured by transepidermal water loss at 2 days and 2 months predates and predicts atopic dermatitis at 1 year.

The Journal of allergy and clinical immunology - 1 Apr 2015

Kelleher Maeve, Dunn-Galvin Audrey, Hourihane Jonathan O'B, Murray Deirdre, Campbell Linda E, McLean W H Irwin, Irvine Alan D

Abstract excerpt

BACKGROUND: Loss-of-function mutations in the skin barrier protein filaggrin (FLG) are a major risk for atopic dermatitis (AD). The pathogenic sequence of disturbances in skin barrier function before or during the early development of AD is not fully understood. A more detailed understanding of these events is needed to develop a clearer picture of disease pathogenesis. A robust, noninvasive test to identify...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25618747
DOI: 10.1016/j.jaci.2014.12.013
PMCID: PMC4382348

Genes

FLG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Skin barrier dysfunction measured by transepidermal water loss at 2 days and 2 months predates and predicts atopic dermatitis at 1 year.PMID 25618747Read ↗

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