Article
Early-life regional and temporal variation in filaggrin-derived natural moisturizing factor, filaggrin-processing enzyme activity, corneocyte phenotypes and plasmin activity: implications for atopic dermatitis.
The British journal of dermatology - 1 Aug 2018
McAleer M A, Jakasa I, Raj N, O'Donnell C P F, Lane M E, Rawlings A V, Voegeli R, McLean W H I, Kezic S, Irvine A D
Abstract excerpt
BACKGROUND: Filaggrin is central to the pathogenesis of atopic dermatitis (AD). The cheeks are a common initiation site of infantile AD. Regional and temporal expression of levels of filaggrin degradation products [natural moisturizing factors (NMFs)], activities of filaggrin-processing enzymes [bleomycin hydrolase (BH) and calpain-1 (C-1)] and plasmin, and corneocyte envelope (CE) maturity in early life are...
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