Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutant GTF2I induces cell transformation and metabolic alterations in thymic epithelial cells.

Cell death and differentiation - 1 Jul 2020

Kim In-Kyu, Rao Guanhua, Zhao Xiaoliang, Fan Ruzong, Avantaggiati Maria Laura, Wang Yisong, Zhang Yu-Wen, Giaccone Giuseppe

Abstract excerpt

The pathogenesis of thymic epithelial tumors (TETs) is poorly understood. Recently we reported the frequent occurrence of a missense mutation in the GTF2I gene in TETs and hypothesized that GTF2I mutation might contribute to thymic tumorigenesis. Expression of mutant TFII-I altered the transcriptome of normal thymic epithelial cells and upregulated several oncogenic genes. Gtf2i L424H knockin cells exhibited cell...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinogenesis
Share to Cyclooxygenase 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epithelial-Mesenchymal Transition

Share to Gene Knock-In Techniques

Share to Glycolysis

Share to NIH 3T3 Cells

Share to Thymus Gland

Share to Transcription Factors, TFII

Source

Open in PubMed Open full text

Identifiers

PMID: 32034314
DOI: 10.1038/s41418-020-0502-7
PMCID: PMC7308410

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutant GTF2I induces cell transformation and metabolic alterations in thymic epithelial cells.PMID 32034314Read ↗

GTF2I mutation frequently occurs in more indolent thymic epithelial tumors and predicts better prognosis.Semantic proximity Read ↗

Human thymoma-associated mutation of the GTF2I transcription factor impairs thymic epithelial progenitor differentiation in mice.Semantic proximity Read ↗

A Knock-In Mouse Model of Thymoma With the GTF2I L424H Mutation.Semantic proximity Read ↗

Integrative Multiomic Classification Reveals Distinct Origins and Evolutionary Trajectories of Thymic Epithelial Tumors.Semantic proximity Read ↗

Genetic alterations leading to thymic epithelial malignanciesSemantic proximity Read ↗

Genomic Analysis of Thymic Epithelial Tumors Identifies Novel Subtypes Associated with Distinct Clinical Features.Semantic proximity Read ↗

The Integrated Genomic Landscape of Thymic Epithelial Tumors.Semantic proximity Read ↗

Primary Driver Mutations in GTF2I Specific to the Development of ThymomasSemantic proximity Read ↗

The Molecular Landscape of Thymic Epithelial Tumors: A Comprehensive ReviewSemantic proximity Read ↗

Thymic epithelial tumors: examining the GTF2I mutation and developing a novel prognostic signature with LncRNA pairs to predict tumor recurrence.Semantic proximity Read ↗

Characteristics of GTF2I L424H Mutated Thymoma and its Prognostic Impact: A Comprehensive StudySemantic proximity Read ↗

Deciphering the biology of thymic epithelial tumorsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.